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Generic Name:

avanafil, Oral tablet

Stendra

Stendra

Generic Name: avanafil, Oral tablet

All Brands

  • Stendra
SECTION 1 of 4

Highlights for Stendra

Oral tablet
1

Stendra is used to treat erectile dysfunction. In this condition, a man is unable to get or keep an erection firm enough to have sexual intercourse.

2

Stendra comes in the form of a tablet you take by mouth.

3

Stendra is available as a brand-name drug called Stendra. It isn’t available as a generic drug.

4

More common side effects of taking Stendra include headache, reddening and warming of your face (flushing), stuffy or runny nose, sore throat, back pain, and changes in your electrocardiogram (EKG).

5

In some cases, Stendra can cause serious side effects. These include heart attack, stroke, and vision and hearing changes.

IMPORTANT INFORMATION

Chest pain or heart attack

Stop sexual activity and seek medical help right away if you have chest pain, dizziness, or nausea. Sexual activity can put a strain on your heart, especially if your heart is already weak from a heart attack or heart disease.

Erection that won’t go away

If you have an erection that lasts more than 4 hours, seek medical help right away.

Vision changes

If you have eye problems, such as sudden vision loss in one or both eyes, stop taking this drug and call your doctor right away.

Hearing changes

Some people may have sudden decrease in or loss of hearing, ringing in the ears, or dizziness while taking this drug. Stop taking this drug and call your doctor right away if you have any of these symptoms.

What is Stendra?

This drug is a prescription drug. It’s available in the form of an oral tablet.

This drug isn’t available as a generic drug. It’s only available as the brand-name drug called Stendra.

This drug shouldn’t be used in combination with other drugs for erectile dysfunction.

How it works

This drug is part of a class of drugs called phosphodiesterase-5 (PDE-5) enzyme inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by relaxing the blood vessels in the penis. This causes increased blood flow and an erection.

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SECTION 2 of 4

Stendra Side Effects

Oral tablet

More Common Side Effects

headache

  • reddening and warming of your face (flushing)

  • stuffy or runny nose

  • sore throat

  • back pain

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • heart attack. Symptoms can include:

    • chest pain
    • shortness of breath
    • discomfort in your upper body
    • dizziness
    • nausea
  • stroke. Symptoms can include:

    • weakness in one part or side of your body
    • slurred speech
  • vision changes. Symptoms can include:

    • decreased vision in one or both eyes
    • loss of vision in one or both eyes
  • hearing changes. Symptoms can include:

    • ringing in your ears
    • dizziness
    • decrease in or loss of hearing
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

Stendra May Interact with Other Medications

Oral tablet

Stendra can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how Stendra might interact with something else you’re taking, talk to your doctor or pharmacist.

Food interactions

You shouldn’t drink grapefruit juice or eat grapefruit while taking Stendra. Doing so can increase levels of this drug in your body. This raises your risk of side effects from this drug.

Alcohol interactions

The use of drinks that contain alcohol can increase your risk of low blood pressure, headache, dizziness, or increased heart rate from Stendra. If you drink alcohol, talk to your doctor, especially if you have more than 3 alcoholic drinks per day.

Medications that might interact with this drug

Chest pain drugs

If you take Stendra with certain drugs to treat chest pain, you may have an unsafe drop in blood pressure. This can make you feel dizzy or faint, or have a heart attack or stroke. You shouldn’t take these drugs together.

These drugs include:

  • nitrates, such as:
    • isosorbide dinitrate
    • isosorbide mononitrate
    • nicorandil
    • nitroglycerin

Antibiotics (macrolides)

Certain antibiotics cause Stendra to increase in your body to an amount that’s too high. This can cause you to have more side effects. You shouldn’t take these drugs together.

These drugs include:

  • clarithromycin
  • telithromycin

Antifungals

Certain antifungals cause Stendra to increase in your body to an amount that’s too high. This can cause you to have more side effects. You shouldn’t take these drugs together.

These drugs include:

  • ketoconazole
  • itraconazole
  • erythromycin
  • fluconazole

Human immunodeficiency virus (HIV) drugs

Certain HIV drugs cause Stendra to increase in your body to an amount that’s too high. This can cause you to have more side effects. You shouldn’t take these drugs together.

These drugs include:

  • nefazadone
  • ritonavir
  • saquinavir
  • nelfinavir
  • indinavir
  • atazanavir
  • amprenavir
  • fosamprenavir

Nausea and vomiting drugs

Certain drugs to treat nausea and vomiting cause Stendra to increase in your body to an amount that’s too high. This can cause you to have more side effects. You shouldn’t take these drugs together.

These drugs include:

  • aprepitant

Blood pressure drugs

Certain blood pressure drugs cause Stendra to increase in your body to an amount that’s too high. This can cause you to have more side effects. You shouldn’t take these drugs together.

These drugs include:

  • calcium channel blockers, such as:
    • diltiazem
    • verapamil

Also, Stendra can increase the blood pressure-lowering effect of certain blood pressure drugs. This can cause symptoms such as dizziness, lightheadedness, or fainting. If these drugs are used together, people should be stable on their blood pressure drug before starting Stendra.

These drugs include:

  • alpha blockers, such as:
    • alfuzosin
    • doxazosin
    • prazosin
    • sildosin
    • tamsulosin
    • terazosin

Seizure drugs

Certain seizure drugs cause Stendra to decrease in your body to an amount that’s too low. This means that it may not work as well. You shouldn’t take these drugs together.

These drugs include:

  • carbamazepine
  • fosphenytoin
  • phenytoin

Barbiturates

These drugs cause Stendra to decrease in your body to an amount that’s too low. This means that it may not work as well. You shouldn’t take these drugs together. 

These drugs include:

  • phenobarbital

Tuberculosis drugs

Certain tuberculosis drugs cause Stendra to decrease in your body to an amount that’s too low. This means that it may not work as well. You shouldn’t take these drugs together.

These drugs include:

  • rifabutin
  • rifampin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug interactions
People with a history of heart disease
People with a history of heart disease

Sexual activity can put a strain on your heart, especially if your heart is already weak from a heart attack or heart disease. You shouldn’t take this drug if you’ve had a heart attack, stroke, life-threatening changes in your heart rhythm, or angioplasty or stenting in your heart within the last 6 months. You also shouldn’t take this drug if you have unstable chest pain, chest pain with sexual intercourse, or severe heart failure.

People with very high or low blood pressure
People with very high or low blood pressure

You shouldn’t take this drug if your blood pressure is less than 90/50 mmHg or higher than 170/100 mmHg at rest. In general, people with these blood pressure values should avoid sexual activity. Also, this drug hasn’t been studied in people with very high or low blood pressure. It’s unknown if this drug is safe or effective in people with these conditions.

People with kidney disease
People with kidney disease

You shouldn’t use this drug if you have severe kidney disease or are on dialysis. It isn’t known how your body will process this drug.

People with liver disease
People with liver disease

You shouldn’t use this drug if you have severe liver disease. It isn’t known how your body will process this drug.

People with a deformed penis shape
People with a deformed penis shape

You may have a higher risk of prolonged or painful erection from this drug. Talk to your doctor about whether this drug is safe for you.

People with sickle cell anemia, multiple myeloma, or leukemia
People with sickle cell anemia, multiple myeloma, or leukemia

You may have a higher risk of prolonged or painful erection from this drug. Talk to your doctor about whether this drug is safe for you.

People with certain blood flow defects in the heart
People with certain blood flow defects in the heart

You may be very sensitive to blood vessel relaxation and the effects of this drug. Talk to your doctor about whether this drug is safe for you.

For children
For children

This medication hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

Allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms can include:

  • itching
  • eyelid swelling
  • shortness of breath
  • trouble breathing

Call 9-1-1 or go to the nearest emergency room if you develop these symptoms.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take Stendra (Dosage)

Oral tablet

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Erectile dysfunction

Brand: Stendra

Form: Oral tablet
Strengths: 50 mg, 100 mg, 200 mg
Adult dosage (ages 18–64 years)

The starting dose is 100 mg taken 15 minutes before sexual activity. Your doctor may increase or decrease your dose based on how you respond to the drug. Don’t take Stendra more than one time per day.

Child dosage (ages 0–17 years)

This medication hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of Stendra from building up too much in your body.

Special considerations

If you’re taking certain drugs, your doctor will start you on a lower dose of 50 mg of Stendra. These include some antibiotics or antifungals and certain human immunodeficiency virus (HIV), prostate, and blood pressure drugs.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all

If you don’t take this drug, your erectile dysfunction won’t improve.

If you miss doses or don’t take the drug on schedule

If you take this drug too soon before sexual activity, it may not have enough time to work properly. If you take it too long before sexual activity, you may not experience the full effects of the drug.

If you take too much

You could have dangerous levels of the drug in your body. You may have the following symptoms:

  • back pain
  • reddening and warming of your face (flushing)
  • nasal congestion
  • common cold (nasopharyngitis)

If you think you’ve taken too much of the drug, act right away. Call your doctor or local poison control center, or go to the nearest emergency room.

What to do if you miss a dose

This drug is taken as needed, about 15 minutes before sexual activity. If you don’t take it before sexual activity, your erectile dysfunction will not improve.

How to tell if the drug is working

You’ll know if this drug is working if you have less erectile dysfunction during sexual activity.

This drug is used for short-term treatment.

Important considerations for taking this drug
take with or without food
You can take this drug with or without food
Don’t take this drug more than one time per day
Don’t take this drug more than one time per day
You can cut or crush the tablet
You can cut or crush the tablet
storage
Store this drug at room temperature
See Details
Prescription is refillable
Prescription is refillable
See Details
Travel
Travel
See Details
Not Usually Stocked
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead.
Insurance
Insurance
See Details

Store this drug at room temperature

  • Keep it from 68°F to 77°F (20°C to 25°C). Keep it away from high temperatures.
  • Don’t store this medication in moist or damp areas, such as bathrooms.
  • Protect this drug from light.

Prescription is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on October 15, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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